Cardiac malformation risk following first trimester methylphenidate use in pregnancy

Researchers from the UK Teratology Information Service have published an updated meta-analysis of studies investigating the risk of cardiac malformation following maternal first trimester methylphenidate use in pregnancy. The findings indicated a small statistically significant increased risk, but the authors advised caution in the interpretation of this finding given that the primary source studies are likely confounded. The brief report of this updated analysis is available (open access) on the Journal of Clincal Psychiatry website (see here).