Data from the North American AED Pregnancy Registry published

Researchers from Harvard T.H. Chan School of Public Health and Mass General Brigham for Children (Boston, USA) have published an updated analysis of data from the North American AED Pregnancy Registry. The study assesses the risk of major malformation among infants of women using common ASM polytherapies during the first trimester. More information is available here. Photo by Polina Tankilevitch […]

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A systematic safety surveillance approach assessing congenital malformation risk following prenatal antipsychotic exposure

Researchers from the Division of Pharmacoepidemiology and Pharmacoeconomics at the Brigham and Women’s Hospital in Boston, USA, have published a study utilising a tree-based scan statistic (TBSS) approach evaluating the risk of a range of specific malformations and malformation groupings and their association with prenatal antipsychotic exposure. More information is available here. Photo by Pankaj Patel on Unsplash

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Target trial emulation studying the timing of high-dose folic acid supplementation among women taking antiseizure medications and malformation risk

A collaboration of researchers from Denmark, Iceland, Norway, and Sweden have published a target trial emulation study assessing the risk of malformation associated with the timing of high-dose folic acid supplementation among women taking antiseizure medications. More information is available here. Photo by Ocean Ng on Unsplash

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Living systematic review of Mpox vaccination in pregnancy

Researchers from the Argentine Cochrane Center have published a living systematic review and meta-analysis investigating the safety and effectiveness of Mpox vaccine in pregnancy and childhood. This initial evidence synthesis described no increased risk of miscarriage, stillbirth or preterm delivery, but a statistical association was observed with malformation risk. More information can be found here. Photo by National Institute of […]

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