Large population-based study of first trimester tetracycline use and major congenital malformation risks

A collaborative of researchers from Karolinska Institutet (Stockholm, Sweden), Norwegian Institute of Public Health (Oslo, Norway) and Statens Serum Institut (Copenhagen, Denmark), have published a large population-based study using Swedish healthcare system datasets to investigate the association between first trimester exposure to tetracyclines and major congenital malformation risks. More information is available here. Photo by Kamal Hoseinianzade on Unsplash

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Berlin TIS demonstrates the use of landmarking for the analysis of left-truncated competing risk data

Landmarking is a statistical methodology which may be able to serve as a an alternative to multistate modelling for the analysis of left-truncated competing risk data. Researchers affiliated with the Berlin TIS (Embryotox Center of Clinical Teratology and Drug Safety in Pregnancy) have published a demonstration of the analytical technique to examine elective termination and spontaneous abortion risks among fluoroquinolone-exposed […]

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Paternal metformin use and risk of congenital malformation

Norwegian and Taiwanese researchers have published a cross national, population-based cohort study investigating malformation risks following paternal metformin use. The findings suggest that paternal use of metformin is not associated with congenital malformation in the offspring, including organ specific malformations. More information is available here. Photo by Mae Mu on Unsplash

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Oropouche virus: Case series of newborns with microcephaly in Brazil

Brazilian researchers have published a case series of newborns with microcephaly in Brazil in which they discuss vertical transmission of Oropouche virus (OROV) as the possible aetiological cause. The authors of the case series conclude that the evidence they present does not confirm vertical transmission or congenital malformations due to OROV disease in pregnancy, but call for priority action in […]

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Systematic review and meta-analysis of studies investigating neonatal outcomes following maternal use of antipsychotics

Researchers affiliated to the ENTIS network, led by Dr Benoit Marin from Centre de Référence sur les Agents Tératogènes (CRAT) in Paris, have published a systematic review and meta-analysis of studies investigating neonatal outcomes following maternal use of antipsychotics. Although potentially confounded, the results indicated associations with birth weight abnormalities and low Apgar scores. More information is available here. Photo […]

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ENTIS Collaborative Study Published – Modafinil

An ENTIS collaborative study has been published investigating maternal modafinil treatment and fetal development and neonatal growth outcomes. This multicenter case series, led by colleagues from TIS Berlin (Embryotox Center of Clinical Teratology and Drug Safety in Pregnancy), used data from 18 Teratology Information Services based in 12 countries. The study has been published with open access in Acta Psychiatrica […]

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Oropouche Virus (OROV) in Pregnancy; a helpful narrative review

Oropouche virus (OROV) is an arbovirus endemic in Latin America and the Caribbean. A recent outbreak of the virus has been associated with reports of pregnant women infected with OROV who have had miscarriages and stillborn fetuses with placental, umbilical blood and fetal somatic organ samples that were RT-PCR positive for OROV and negative for other arboviruses. Travelers with Oropouche […]

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ENTIS partners develop new algorithm to detect and date early non-live pregnancy outcomes in linked Norwegian health registries

ENTIS members from the University of Oslo have developed a novel algorithm to more completely detect and date early pregnancy outcomes (i.e., miscarriages, elective terminations, ectopic pregnancies, molar pregnancies, stillbirths, and live births) using diagnostic codes from primary and secondary care registries to complement information from the national birth registry. More information can be found here. Photo by Luke Chesser […]

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