Cardiac malformation risk following first trimester methylphenidate use in pregnancy

Researchers from the UK Teratology Information Service have published an updated meta-analysis of studies investigating the risk of cardiac malformation following maternal first trimester methylphenidate use in pregnancy. The findings indicated a small statistically significant increased risk, but the authors advised caution in the interpretation of this finding given that the primary source studies are likely confounded. The brief report […]

» Read more

Comment on the latest meta-analysis investigating childhood neurodevelopment outcomes following acetaminophen (paracetamol) use in pregnancy

Professor Per Damkier (University of Southern Denmark), Chair of the ENTIS Scientific committee, has provided a comment on the most recent meta-analysis investigating in utero exposure to acetaminophen and childhood neurodevelopment (Ricci et al., 2023). In this comment, published in Paediatric and Perinatal Epidemiology, Prof Damkier highlights important key methodological limitations and notable conflicting findings in the primary source literature. […]

» Read more

In utero antiseizure medication exposure and the risk of psychiatric disorders

A collaborative of Scandinavian researchers led from Aarhus University in Denmark have published a large prospective, population-based register study including over 4.5 million study subjects which investigated the risk of psychiatric disorders following in utero ASM exposure. The study findings indicate that n utero valproate, topiramate and levetiracetam exposure may be associated with increased risks of neurodevelopmental impairment, ADHD and/or […]

» Read more

Antipsychotic use in pregnancy and congenital malformation risk

Researchers from Aarhus University in Denmark have published an updated analysis of linked data collected from Danish population-based healthcare registers, investigating major malformation risks among pregnancies exposed to antipsychotics in the first trimester in comparison with unexposed pregnancies. Robust sensitivity analyses were also conducted, including comparisons formed between exposed pregnancies, and pregnancies among women who only used antipsychotics prior to […]

» Read more

ConcePTION Webinar Invite: Using real word data for research on medication safety during pregnancy and breastfeeding

On 20 April 2023, 1400-1500 CEST, experts from Work Package 7 of the ConcePTION project will present a discussion of the opportunities and challenges of using real-world data to study medicine safety during pregnancy and breastfeeding. You can register to join this free and open-access webinar to learn more about how real-world data can inform clinical and regulatory decision-making, and […]

» Read more

Observational study of newer anti-seizure medication use in pregnancy; focus on lacosamide

Researchers and ENTIS members from the Embryotox Center of Clinical Teratology and Drug Safety in Pregnancy, in Berlin, have published an observational study of newer anti-seizure medication use in pregnancy. The study has a focus on lacosamide, describing 55 prospective and 10 retrospective exposures. More information is available here, where the paper is openly available until 19th May 2023.

» Read more
1 2 3 19