UK RCOG COVID-19 and Pregnancy Guidelines Updated

Guidance for healthcare professionals on managing coronavirus (COVID-19) infection in pregnancy has been jointly published by the UK Royal College of Obstetricians and Gynaecologists, Royal College of Midwives and Royal College of Paediatrics and Child Health, with input from the Royal College of Anaesthetists, Public Health England and Health Protection Scotland. The updates included in these guidelines reflect recent changes […]

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Danish study describes a clinically important increased risk of major congenital malformation associated with first trimester modafinil exposure

Lead author of the study and ENTIS member Professor Per Damkier from the Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Denmark, stated that there appears to be about a 3-fold increased risk – while we have a relatively small number of exposed and outcomes (N=49; 6 major malformations), and hence a low precision – the signal is strong […]

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Systematic review and meta-analysis of adverse pregnancy outcome risk following abnormal 1 hour glucose challenge test results

Researchers from the University of South Florida have published a systematic review and meta-analysis investigating the adverse pregnancy outcome risks associated with abnormal 1-h 50-g glucose challenge test (GCT) followed by a normal 3-h 100-g glucose tolerance test (GTT). More information can be found here. Photo by Sharon McCutcheon on Unsplash

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New data published regarding the risk of fetal loss following antimalarial use in pregnancy

Researchers from the US Center for Disease Control and Prevention and the Naval Health Research Centre in San Diego have published an analysis of the fetal loss (spontaneous abortion and stillbirth combined) rates among active duty military women using antimalarial medications during pregnancy. More information can be found here. Photo by Егор Камелев on Unsplash

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No detectable increased risk of birth defects following maternal IV administration of ondansetron

Researchers from the Brigham and Women’s Hospital in Boston (MA) and the Harvard T.H. Chan School of Public Health have published an update to their 2018 study (see here). The authors state that this update was provided to specifically address the findings of another study published in early 2019 (see here) which suggested an association between the clinical administration of […]

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