Consensus recommendations on the management of depressive disorders in pregnancy

The Italian Societies of Toxicology, Neuropsychopharmacology, Psychiatry, Obstetrics and Gynecology, Drug Addiction, and Addiction Pathology have published joint consensus recommendations regarding the management of depressive disorders in pregnancy. These recommendations focussed on five key areas including: (i) the importance of management of anxiety and depressive disorders in pregnancy; (ii) the overall risk of malformation with antidepressant and anxiolytic drugs; (iii) […]

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Congenital malformation risks following integrase inhibitor use in pregnancy

Utilising data from the Colorado-based Children’s Hospital Immunodeficiency Program (CHIP), a team of researchers have published a retrospective comparative cohort study of pregnancy and fetal outcomes following first trimester integrase inhibitor use (dolutegravir, elvitegravir or raltegravir). The study describes increased risks of congenital anomalies among the first trimester integrase inhibitor exposed in comparison with those born to women with HIV […]

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Expert consensus published focusing on the study of neurodevelopmental outcomes in pregnancy drug safety studies

Experts from 13 countries and professionally diverse backgrounds took part in the development of a series of recommendations focusing on the importance of including the study of infant neurodevelopment as a core feature of pregnancy drug safety studies. These recommendations outline the core neurodevelopmental outcomes, optimization of methodological approaches and barriers to conducting pregnancy drug safety studies including neurodevelopmental outcomes. […]

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