Systematic review and meta-analysis of studies investigating neonatal outcomes following maternal use of antipsychotics

Researchers affiliated to the ENTIS network, led by Dr Benoit Marin from Centre de Référence sur les Agents Tératogènes (CRAT) in Paris, have published a systematic review and meta-analysis of studies investigating neonatal outcomes following maternal use of antipsychotics. Although potentially confounded, the results indicated associations with birth weight abnormalities and low Apgar scores. More information is available here. Photo […]

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ENTIS Collaborative Study Published – Modafinil

An ENTIS collaborative study has been published investigating maternal modafinil treatment and fetal development and neonatal growth outcomes. This multicenter case series, led by colleagues from TIS Berlin (Embryotox Center of Clinical Teratology and Drug Safety in Pregnancy), used data from 18 Teratology Information Services based in 12 countries. The study has been published with open access in Acta Psychiatrica […]

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Oropouche Virus (OROV) in Pregnancy; a helpful narrative review

Oropouche virus (OROV) is an arbovirus endemic in Latin America and the Caribbean. A recent outbreak of the virus has been associated with reports of pregnant women infected with OROV who have had miscarriages and stillborn fetuses with placental, umbilical blood and fetal somatic organ samples that were RT-PCR positive for OROV and negative for other arboviruses. Travelers with Oropouche […]

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ENTIS partners develop new algorithm to detect and date early non-live pregnancy outcomes in linked Norwegian health registries

ENTIS members from the University of Oslo have developed a novel algorithm to more completely detect and date early pregnancy outcomes (i.e., miscarriages, elective terminations, ectopic pregnancies, molar pregnancies, stillbirths, and live births) using diagnostic codes from primary and secondary care registries to complement information from the national birth registry. More information can be found here. Photo by Luke Chesser […]

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Suspected vertical transmission of Oropouche virus in pregnancy

The Pan American Health Organizartion (PAHO) has issued an epidemiological alert describing possible cases of vertical Oropouche virus transmission (from mother to fetus) in Brazil. The alert describes two recent cases of suspected vertical transmission in pregnancy, one of which ended in intrauterine fetal death, the second in early pregnancy miscarriage. The alert also describes a small number of historical […]

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Manufacturer of golimumab publishes pregnancy safety data

Pregnancy safety data for golimumab have been published using global pharmacovigilance data collected by Janssen Pharmaceuticals. The authors of the publication concluded that rates of adverse pregnancy outcomes and major congenital anomalies in prospectively reported pregnancy cases were consistent with published background rates for the general population. More information can be found here.

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No increased risk of major malformation following first trimester fluoroquinolone use

Researchers from the Pregnancy and Drug Information Center in Tokyo have published a comparative cohort study comparing fetal malformation outcomes between those exposed to (i) fluoroquinolones (fluoroquinolone group), (ii) β-lactams (infectious control group), or (iii) other agents considered to be nonteratogenic in humans (nonteratogenic control group) during the first trimester. The incidence of major congenital anomalies was not found to […]

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