Category: News

A collaboration of researchers from Aarhus University, University of Southern Denmark and the University of Copenhagen have published a nationwide population-based cohort study using Danish national registry datasets to investigate associations between prenatal exposure to systemic glucocorticoids and neurodevelopmental impairments. The study, which attempted to stratify glucocorticoid exposure due to prematurity (as a known risk factor for neurodevelopmental impairment), produced […]

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Researchers from the Embryotox Center of Clinical Teratology and Drug Safety in Pregnancy (TIS Berlin) at the Institute of Clinical Pharmacology and Toxicology (Charité – Universitätsmedizin) have published data from the German Embryotox cohort (2000 to 2018) analysing trends in antiseizure medication (ASM) use at conception and changes in first trimester treatment pattern among those with epilepsy as reported to […]

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Researchers from the Department of Neurology at the St. Josef-Hospital in Bochum Germany, have published an updated dataset from the German Multiple Sclerosis Pregnancy Registry, comparing pregnancy outcomes between disease-modifying therapy exposed and non-exposed pregnancies. More information can be found here. Photo by freestocks on Unsplash

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A collaborative of researchers from Karolinska Institutet (Stockholm, Sweden), Norwegian Institute of Public Health (Oslo, Norway) and Statens Serum Institut (Copenhagen, Denmark), have published a large population-based study using Swedish healthcare system datasets to investigate the association between first trimester exposure to tetracyclines and major congenital malformation risks. More information is available here. Photo by Kamal Hoseinianzade on Unsplash

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Landmarking is a statistical methodology which may be able to serve as a an alternative to multistate modelling for the analysis of left-truncated competing risk data. Researchers affiliated with the Berlin TIS (Embryotox Center of Clinical Teratology and Drug Safety in Pregnancy) have published a demonstration of the analytical technique to examine elective termination and spontaneous abortion risks among fluoroquinolone-exposed […]

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Norwegian and Taiwanese researchers have published a cross national, population-based cohort study investigating malformation risks following paternal metformin use. The findings suggest that paternal use of metformin is not associated with congenital malformation in the offspring, including organ specific malformations. More information is available here. Photo by Mae Mu on Unsplash

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Brazilian researchers have published a case series of newborns with microcephaly in Brazil in which they discuss vertical transmission of Oropouche virus (OROV) as the possible aetiological cause. The authors of the case series conclude that the evidence they present does not confirm vertical transmission or congenital malformations due to OROV disease in pregnancy, but call for priority action in […]

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Researchers from the Department of Pharmacology at the All India Institute of Medical Sciences have published a systematic review and meta-analysis investigating the risk of congenital anomalies in following exposure to dolutegravir-based-regimens in pregnancy. More information is available here. Photo by National Institute of Allergy and Infectious Diseases on Unsplash

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