Researchers from University College London Great Ormond Street Institute of Child Health have published a timely study of more than 900 pregnancies in patients with HIV exposed to integrase strand inhibitors, raltegravir or elvitegravir. More information here. Photo by Thought Catalog on Unsplash
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A collaborative of researchers from Manchester University, The University of Liverpool and Aston University have demonstrated that intellectual difficulties are a central feature of fetal valproate syndrome, and are more severe in their presentation in individuals with a diagnosis of valproate embryopathy. Full details of the study have been published in Neurotoxicology and Teratology. Photo by Ben Mullins on Unsplash
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A systematic review and meta-analysis published in Human Vaccines and Immunotherapeutics which combined data from up to 40 studies of inactivated influenza vaccine exposure in pregnancy, has provided reassuring data concerning preterm delivery, low birth weight, congenital abnormalities and stillbirth risks. Photo by Hyttalo Souza on Unsplash
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New article published in British Medical Bulletin discusses the management of hypertension during pregnancy.
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Researchers from the Mahidol-Oxford Tropical Medicine Research Unit have published an excellent article in Expert Opinion in Drug Safety which discusses the treatment and prevention of malaria in pregnancy and breastfeeding. Photo by Егор Камелев on Unsplash
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New study published in Annals of Internal Medicine suggests that maternal use of β-blockers in the first trimester is not associated with a large increase in the risk for overall malformations or cardiac malformations, independent of measured confounders. Photo by rawpixel on Unsplash
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A small retrospective case series of pregnancies reported to an industry pharmacovigilance database has provided an additional 53 pregnancy outcomes following gestational adalimumab exposure. Findings from the study were published in Digestive Diseases. Photo by rawpixel on Unsplash
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A multi-centre observational study of vedolizumab use in pregnancy has been published in the Journal of Crohn’s and Colitis which provides a small amount of additional safety information. Photo by John Looy on Unsplash
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A collaborative of researchers from the University of York, AbbVie Biopharmaceuticals and the University of Pennsylvania have published an interesting feasibility study into the use of social media data for the purposes of pregnancy pharmacovigilance in Drug Safety. Photo by William Iven on Unsplash
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Researchers from the University of Montreal have published a methodological paper describing analytical techniques which may be useful for assessing the extent and impact of selection bias which may arise as a consequence of delayed cohort inclusion. The study demonstrates three analytical approaches utilising a regional administrative dataset; full details are published in Pharmacology Research and Perspectives. Photo by freestocks.org on Unsplash
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