Collaborative ENTIS study published investigating the safety of GLP1 receptor agonists in early pregnancy

A collaborative ENTIS study, led by the Swiss Teratogen Information Service and Clinical Pharmacology Service at the Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne in Switzerland, has been published in BMJ Open. This multicentre, observational prospective cohort study compared pregnancy outcomes between women exposed to GLP1-RA in early pregnancy and those with diabetes exposed to at least one […]

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Vaccine willingness and impact of the COVID-19 pandemic on women’s perinatal experiences

Collaborators from ENTIS and affiliated organisations have published the results of a web-based survey investigating vaccine willingness among pregnant and breastfeeding women, and how the first wave of the COVID-19 pandemic impacted women’s perinatal experiences. This multinational survey was promoted in Ireland, Norway, Switzerland, the Netherlands, and the UK between 16 June and 14 July 2020, and identified considerable vaccine […]

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Pregnant and breastfeeding women’s mental health status during the first wave of the COVID-19 pandemic

Collaborators from ENTIS and affiliated organisations have published the results of a web-based survey investigating how the first wave of the COVID-19 pandemic impacted the mental health status of pregnant and breastfeeding women. This multinational survey was promoted in Ireland, Norway, Switzerland, the Netherlands, and the UK between 16 June and 14 July 2020, and identified high levels of depressive […]

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ENTIS study into how the COVID-19 pandemic is impacting the experiences of pregnant and breastfeeding women

Led by Dr Michael Ceulemans from KU Leuven in Belgium, researchers from several ENTIS affiliated organisations, including the University of Oslo, UKTIS, Swiss TIS/University Hospital of Lausanne, Lareb (the Netherlands TIS), and the Irish Medicines in Pregnancy and breastfeeding Service (IMPS), have been promoting an online survey to collect information on how the COVID-19 pandemic has affected the experiences of […]

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Collaborative ENTIS study into the risk of adverse pregnancy outcomes following maternal varenicline use

A collaborative ENTIS study recently published in Reproductive Toxicology (Volume 67, Pages 26-34) has provided no signal that varenicline is a major human teratogen. This collaborative ENTIS study was undertaken by researchers based at teratology information services in the United Kingdom, Israel, France (Paris), Germany (Berlin), Australia, the Netherlands, Finland and Turkey (Izmir), who collectively joined data from over 400 […]

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Publication of recent study of pregnancy outcome after methylphenidate exposure

A collaborative study published in J Clin Psychiatry by ENTIS and MotherToBaby affiliated researchers did not suggest that first trimester in utero exposure be associated with increased risk of congenital malformations.   Methylphenidate is a central nervous system stimulant medicinally used in the treatment of attention deficit disorders. Data on its safety in human pregnancy are sparse. A recent prospective, comparative, […]

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Recent letter by ENTIS members question the EMA warning on Paternal Use of Mycophenolate Mofetil

Changing of the Guards: EMA Warning on Paternal Use of Mycophenolate Mofetil: An Unnecessary and Insufficiently Substantiated Precaution. Damkier P, Passier A, Petersen LB, Havnen G, Petersen AJT. Birth Defects Res A Clin Mol Teratol. 2016 Sep 28. doi: 10.1002/bdra.23556 In this commentary, we strongly argue against the changes to the Summary of Product Characteristics (SmPC) made by European Medicines […]

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Recent ENTIS study investigates the pregnancy outcomes after pregabalin exposure

A collaborative ENTIS study published in Neurology found an increased frequency of major malformations following exposure to pregabalin during the first trimester of pregnancy. Eight member centers of the European Network for Teratovigilance Information Services (ENTIS) conducted a study, which aimed at recording the incidence of malformations after pregabalin use during the first trimester of pregnancy [1]. Pregabalin, an anti-seizure drug, is […]

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