Category: major congenital malformations

Collaborative ENTIS study into the risk of adverse pregnancy outcomes following maternal varenicline use

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A collaborative ENTIS study recently published in Reproductive Toxicology (Volume 67, Pages 26-34) has provided no signal that varenicline is a major human teratogen. This collaborative ENTIS study was undertaken by researchers based at teratology information services in the United Kingdom, Israel, France (Paris), Germany (Berlin), Australia, the Netherlands, Finland and Turkey (Izmir), who collectively joined data from over 400 […]

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Antipsychotics in Pregnancy: Large Cohort Study from the US Investigates Risk for Congenital Malformations

antipsychotics, major congenital malformations, News, study

In August 2016 JAMA Psychiatry published the results of a large pharmacoepidemiological cohort study by Krista Huybrechts et al., examining the risk for congenital malformations overall as well as cardiac malformations associated with first-trimester exposure to antipsychotics. While previous studies documented the outcome of several hundred exposed pregnancies at most, this study cohort included a nationwide sample of more than […]

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