Neurocognitive outcomes following in utero antiseizure medication use

Researchers from The University of Melbourne (Australia) have published an analysis of data collected in the Raoul Wallenberg Australian Pregnancy Register of Antiepileptic Drugs. The study investigates whether in utero exposure to specific types of ASM monotherapies is associated with poorer neurocognitive outcomes compared with ASM-unexposed children. More information is available here. Photo by Anna Shvets on Pexels.

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Systematic review and meta-analysis published conducting a pairwise comparative safety analysis of anti-TNF blockers, vedolizumab and ustekinumab

An international collaboration of researchers have published a systematic review and meta-analysis comparing the safety of anti-TNF blockers, vedolizumab and ustekinumab in pregnancy. Although higher risks were observed for vedolizumab and ustekinumab in comparison with anti-TNF inhibitors, the authors concluded that this was likely related to longer disease duration, prior biologic exposure, and more active disease, More information is available […]

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Data from the North American AED Pregnancy Registry published

Researchers from Harvard T.H. Chan School of Public Health and Mass General Brigham for Children (Boston, USA) have published an updated analysis of data from the North American AED Pregnancy Registry. The study assesses the risk of major malformation among infants of women using common ASM polytherapies during the first trimester. More information is available here. Photo by Polina Tankilevitch […]

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A systematic safety surveillance approach assessing congenital malformation risk following prenatal antipsychotic exposure

Researchers from the Division of Pharmacoepidemiology and Pharmacoeconomics at the Brigham and Women’s Hospital in Boston, USA, have published a study utilising a tree-based scan statistic (TBSS) approach evaluating the risk of a range of specific malformations and malformation groupings and their association with prenatal antipsychotic exposure. More information is available here. Photo by Pankaj Patel on Unsplash

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Target trial emulation studying the timing of high-dose folic acid supplementation among women taking antiseizure medications and malformation risk

A collaboration of researchers from Denmark, Iceland, Norway, and Sweden have published a target trial emulation study assessing the risk of malformation associated with the timing of high-dose folic acid supplementation among women taking antiseizure medications. More information is available here. Photo by Ocean Ng on Unsplash

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