Letter to the Editor: Safety of proton pump inhibitors during pregnancy

ENTIS colleagues from the Teratology Information, Training and Research Center, Terafar at Izmir Katip Celebi University in Turkey have written a letter to the editor of the Alimentary Pharmacology and Therapeutics journal highlighting some key limitations in a systematic review and meta-analysis of proton pump inhibitor use in pregnancy which was published in January 2020. The authors response to the […]

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Study comparing buprenorphine and methadone in the management of maternal opioid use disorder

Researchers from the Renaissance School of Medicine at Stony Brook University (New York, USA) have conducted a retrospective analysis of pregnancy outcomes among women with opioid use disorder. In this study the researchers compared those receiving buprenorphine and methadone treatment. The results suggested improved outcomes among the buprenorphine exposed with a lower incidence of low birth weight, a reduced need […]

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Study investigates associations between maternal antihistamine use in pregnancy and fetal malformation

Researchers from the National Birth Defects Prevention Study have performed an analysis of their data (collected between 1997 and 2011) to identify possible associations between maternal antihistamine use in pregnancy and fetal malformation. Although several statistical signals were identified, the authors concluded, “Only a few of our findings were consistent with previous studies” and “There is a lack of strong […]

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Large, population-based cohort study finds no evidence that seasonal influenza vaccine is associated with major malformation

Researchers from the London School of Hygiene and Tropical Medicine and Queen Mary University of London have analysed pseudonymised UK primary care data from the Clinical Practice Research Datalink to investigate malformation risks following seasonal influenza vaccination exposure in pregnancy. They found no evidence for an increased risk following exposure at any stage of pregnancy or in the first trimester […]

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Narrative review published summarising the impact of coronaviruses on pregnant women

Researchers from Lausanne University Hospital and the Swiss Institute of Primary Health Care have published a narrative review which summarises the existing knowledge about how coronaviruses (including MERS, SARS and SARS-CoV-2) can impact pregnant patients. The review also includes a useful discussion of the therapeutic treatment options available for pregnant women, and contrasts existing antenatal management guidance proposed by RCOG, […]

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Study investigating neurodevelopment outcomes following caffeine consumption in pregnancy

Researchers from the University of Gothenburg and the Norwegian Institute of Public Health have published a study conducted using data from the Norwegian Mother, Father and Child Cohort Study, which has investigated the impact of maternal caffeine consumption during pregnancy on offspring neurodevelopment. More information can be found here. Photo by Mike Kenneally on Unsplash

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Oral fluconazole associated with a small increase in the risk of musculoskeletal malformation

A collaborative of researchers from Harvard Medical School, Brigham and Women’s Hospital Boston and Harvard T H Chan School of Public Health have analysed data from the Medicaid Analytic eXtract and found a small increase in the risk of musculoskeletal malformation following first trimester oral fluconazole use. More information cab be found here. Photo by kgrkz on Unsplash

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