Paracetamol use in the third trimester does not seem to be associated with a relevant risk of prenatal ductus arteriosus closure or fetal renal impairment

The team at Embryotox Berlin (TIS Berlin) in conjunction with a colleague from Beuth Hochschule für Technik-University of Applied Sciences in Berlin have conducted a study to examine the risk of fetal cardiovascular or renal toxicity following maternal third trimester paracetamol use. More information can be found here. Photo by Robina Weermeijer on Unsplash

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Continued folic acid supplementation beyond the early stages of pregnancy may have beneficial effects on child cognitive development

A collaboration of reserchers from Ulster University, Causeway Hospital in Northern Ireland, the Royal-Jubilee Maternity Service in Belfast, Universtiy College Dublin and Trinity College Dublin have published an update of their FASSTT Offspring Trial. This randomised controlled trial originally compared pregnancy outcomes between women treated with 400 micrograms of folic acid and placebo exposed controls. This latest update to the […]

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Collaborative ENTIS Study: Fetotoxic effects of ARBs exceeds that of ACE-Is

A collaboration of researchers from six ENTIS affiliated organisations and led by researchers at the Berlin TIS (Embryotox) have published their findings investigating the risk of fetotoxicity following maternal ARB or ACE-I use in pregnancy. The results of this research has suggested that, following use for at least 20 weeks of gestation, exposure to ARBs is associated with a higher […]

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Using twitter for birth defect epidmiology purposes

A collaborative of researchers from the Perelman School of Medicine University of Pennsylvania and Emory University School of Medicine have published an interesting article detailing their experience of developing a machine learning based system to survey pubically available Twitter posts for birth defect epidmiology purposes. More information can be found here. Photo by Kon Karampelas on Unsplash

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An interesting discussion of possible methodological approaches for dealing with data confounding

The findings of post-marketing observational studies are generally limited by the impact of data confounding, but there are useful study designs which can partially address this important limitation. An article has been published in the Journal of Clinical Psychiatry discussing these methodological approaches. More information can be found here. Photo by Annie Spratt on Unsplash

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Most common birth defects among the infants of women with diabetes in pregnancy

A collaboration of researchers from the Centers for Disease Control and Prevention’s National Center on Birth Defects and Developmental Disabilities, the University of Texas, Emory Univeristy and the University of Utah have published an analysis of data collected by the National Birth Defects Prevention Study (1997-2011) to describe the defects most commonly observed among the infants of women with pregestational […]

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