Disproportionality analysis of pregnancy CFTR modulator reports in VigiBase

ENTIS affiliated researchers from the Swiss TIS (University of Lausanne), Ente Ospedaliero Cantonale (Lugano) and Centre Hospitalier Universitaire Vaudois (CHUV, Lausanne) have published a disproportionality analysis of the VigiBase World Health Organization global pharmacovigilance database, to identify signals of disproportionate reporting for pregnancy-related adverse drug reactions associated with elexacaftor, ivacaftor, tezacaftor and lumacaftor. More information is available here. Photo by […]

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Critical evaluation published on the latest review of neurodevelopmental disorders following in utero exposure to acetaminophen (paracetamol)

Professor Per Damkier (Department of Clinical Pharmacology, Odense University Hospital, Denmark) has produced a critical evaluation of the recent navigation guide review of evidence on acetaminophen (paracetamol) use in pregnancy and neurodevelopmental disorders in the offspring (see the navigation guide review here).

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Systematic review and meta-analysis of pregnancy outcomes following paternal methotrexate exposure published

Researchers from Izmir TIS (Terafar), the Department of Medical Pharmacology, Marmara University School of Medicine, and the Turkish Medicines and Medical Devices Agency have published a systematic review and meta-analysis of pregnancy outcomes following paternal methotrexate exposure. More information is available here. Photo by Towfiqu barbhuiya, downloaded from Pexels.

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Commentary published on the FDA panel discussion about SSRI use in pregnancy

Professor Per Damkier (the outgoing Chair of the ENTIS Scientific Committee) and Dr Matitiahu Berkovitch (President of ENTIS) have published a commentary in the British Journal of Obstetrics and Gynaecology discussing the FDA panel discussion (broadcast 21 July 2025) about the safety of selective serotonin reuptake inhibitors (SSRI) in pregnancy. Photo by Sam Szuchan on Unsplash

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Umbrella review of systematic reviews investigating claims of increased ASD and ADHD risks following maternal paracetamol use published

Researchers from Liverpool University have published an umbrella review of systematic reviews investigating maternal paracetamol (acetaminophen) use during pregnancy and risk of autism spectrum disorder and attention deficit/hyperactivity disorder. The authors concluded that confidence in the current evidence was considered low to critically low. More information is available here. Photo by James Yarema on Unsplash

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Commentary published discussing a recent study of acetaminophen exposure and childhood attention deficit hyperactivity disorder

ENTIS members Prof Per Damkier and Dr Erika Gram have published a commentary discussing the methodological advantages and limitations of a new study of Commentary published discussing a recent study of acetaminophen exposure and childhood attention deficit hyperactivity disorder (Baker et al. 2025 – see here). Photo by Tara Winstead downloaded from Pexels

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