Collaborative ENTIS study published investigating the safety of GLP1 receptor agonists in early pregnancy

A collaborative ENTIS study, led by the Swiss Teratogen Information Service and Clinical Pharmacology Service at the Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne in Switzerland, has been published in BMJ Open. This multicentre, observational prospective cohort study compared pregnancy outcomes between women exposed to GLP1-RA in early pregnancy and those with diabetes exposed to at least one […]

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Sibling controlled cohort study finds no evidence for an increased risk of autism, ADHD or intellectual disability following paracetamol (acetaminophen) use in pregnancy

Researchers from the Karolinska Institutet in Stockholm, Sweden, have published a population-based cohort study examining the risks of autism, ADHD or intellectual disability following paracetamol (acetaminophen) use in pregnancy. No increased risks were identified in sibling control analyses, suggesting that associations observed in other models (i.e. non-sibling controlled) may have been attributable to confounding. More information is available here.

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Study finds no increased risk of autism spectrum disorder with maternal topiramate use in pregnancy

A large population-based cohort study using data from US healthcare utilisation databases (Medicaid and MarketScan) suggests that topiramate use in pregnancy may not be associated with an increased risk of autism. More information is available here, This finding contrasts with a 2022 study which suggested an almost 3-fold increased risk following in utero topiramate exposure. A helpful overview of these […]

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