Motherisk Journal Article: How much folic acid is sufficient in women using antiepileptic drugs during pregnancy?

Professor Yusuf Kaplan, formerly of the Izmir TIS, and Professor Gideon Koren from the Adelson Faculty of Medicine, Ariel University, Israel and the Motherisk Israel Program have published a review article discussing the available evidence regarding the folic acid requirements for women who use antiepileptic drugs in pregnancy. More information can be found here. Photo by Iñigo De la Maza on Unsplash

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Small increased risk of birth defects following first trimester hydroxychloroquine use

A collaborative of researchers from Harvard University’s Medical School and School of Public Health have published a propensity score matched analysis of US Medicaid data which has identified a small increased risk of overall malformation following first trimester hydroxychloroquine use in the treatment of rheumatic conditions. The small increased risk predicted by this study suggest that an additional case of malformation could […]

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Letter to the Editor: Safety of proton pump inhibitors during pregnancy

ENTIS colleagues from the Teratology Information, Training and Research Center, Terafar at Izmir Katip Celebi University in Turkey have written a letter to the editor of the Alimentary Pharmacology and Therapeutics journal highlighting some key limitations in a systematic review and meta-analysis of proton pump inhibitor use in pregnancy which was published in January 2020. The authors response to the […]

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Study comparing buprenorphine and methadone in the management of maternal opioid use disorder

Researchers from the Renaissance School of Medicine at Stony Brook University (New York, USA) have conducted a retrospective analysis of pregnancy outcomes among women with opioid use disorder. In this study the researchers compared those receiving buprenorphine and methadone treatment. The results suggested improved outcomes among the buprenorphine exposed with a lower incidence of low birth weight, a reduced need […]

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Study investigates associations between maternal antihistamine use in pregnancy and fetal malformation

Researchers from the National Birth Defects Prevention Study have performed an analysis of their data (collected between 1997 and 2011) to identify possible associations between maternal antihistamine use in pregnancy and fetal malformation. Although several statistical signals were identified, the authors concluded, “Only a few of our findings were consistent with previous studies” and “There is a lack of strong […]

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Large, population-based cohort study finds no evidence that seasonal influenza vaccine is associated with major malformation

Researchers from the London School of Hygiene and Tropical Medicine and Queen Mary University of London have analysed pseudonymised UK primary care data from the Clinical Practice Research Datalink to investigate malformation risks following seasonal influenza vaccination exposure in pregnancy. They found no evidence for an increased risk following exposure at any stage of pregnancy or in the first trimester […]

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