Researchers from Lyon, France have published an updated systematic review and meta-analysis of malformation risk following maternal first trimester proton pump inhibitor exposure. More information can be found here.
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Researchers from Qilu Medical University, China, have published a comparative analysis of the safety of propylthiouracil and methimazole in the treatment of hyperthyroidism in pregnancy. More information can be found here. Photo by SHAMBHAVI SINGH on Unsplash
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Researchers and ENTIS affiliates from KU Leuven, Belgium, have published details of their newly developed BELpREG data registration system which enables comprehensive “real-world” data collection on perinatal medication use and mother-infant outcomes via online questionnaires. More information about the development and design of the system available here.
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Researchers from the HealthPartners Institute in Minneapolis, Minnesota (USA) have led the publication of a study using the Vaccine Safety Datalink (November 2021 to June 2022), comparing rates of third dose mRNA vaccine exposure in the 28 days prior to miscarriage or ongoing pregnancy. More information is available here.
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Researchers from the UK Teratology Information Service have published an updated meta-analysis of studies investigating the risk of cardiac malformation following maternal first trimester methylphenidate use in pregnancy. The findings indicated a small statistically significant increased risk, but the authors advised caution in the interpretation of this finding given that the primary source studies are likely confounded. The brief report […]
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Professor Per Damkier (University of Southern Denmark), Chair of the ENTIS Scientific committee, has provided a comment on the most recent meta-analysis investigating in utero exposure to acetaminophen and childhood neurodevelopment (Ricci et al., 2023). In this comment, published in Paediatric and Perinatal Epidemiology, Prof Damkier highlights important key methodological limitations and notable conflicting findings in the primary source literature. […]
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A collaborative of Scandinavian researchers led from Aarhus University in Denmark have published a large prospective, population-based register study including over 4.5 million study subjects which investigated the risk of psychiatric disorders following in utero ASM exposure. The study findings indicate that n utero valproate, topiramate and levetiracetam exposure may be associated with increased risks of neurodevelopmental impairment, ADHD and/or […]
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Researchers from Odense University Hospital in Denmark have published the results of a population-based observational comparative cohort study investigating pregnancy and infant outcomes following maternal corticosteroid use to treat inflammatory bowel disease (IBD). More information available here.
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Researchers from Aarhus University in Denmark have published an updated analysis of linked data collected from Danish population-based healthcare registers, investigating major malformation risks among pregnancies exposed to antipsychotics in the first trimester in comparison with unexposed pregnancies. Robust sensitivity analyses were also conducted, including comparisons formed between exposed pregnancies, and pregnancies among women who only used antipsychotics prior to […]
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On 20 April 2023, 1400-1500 CEST, experts from Work Package 7 of the ConcePTION project will present a discussion of the opportunities and challenges of using real-world data to study medicine safety during pregnancy and breastfeeding. You can register to join this free and open-access webinar to learn more about how real-world data can inform clinical and regulatory decision-making, and […]
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