Prospective case series of pregnancy outcomes following gestational CFTR modulator use published

A new collaboration between the Teratology Information Service CRAT (Centre de Reference sur les Agents Tératogènes) and the French Network of Pharmacovigilance Centres has produced the largest to date prospective case series of CFTR modulator exposed pregnancies. The article has been published in the Journal of Cystic Fibrosis, and more details are available here. Photo by Robina Weermeijer on Unsplash

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Latest publications from TIS Paris Cochin

Recent research conducted at TIS Paris Cochin includes: A comprehensive analysis into the safety of ifosfamide in pregnancy, including a review of literature cases, cases in the French pharmacovigilance database, and a disproportionality analysis of Vigibase. A comparative cohort study of pregnancy outcomes following CFTR modulator use in pregnancy. A nationwide cohort study investigating the impact of clomiphene citrate on […]

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Risk of autism spectrum disorder following maternal antiseizure medication use in pregnancy

A collaborative group of Brazilian researchers has published a systematic review and meta analysis of autism spectrum disorder risk following maternal antiseizure medication (ASM) use in pregnancy. The updated analysis provides pooled risk estimates for specific ASMs, demonstrating increased risks for carbamazepine, valproate and oxcarbazepine. More information can be found here.

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EULAR 2024 update published

An update to the existing European Alliance of Associations for Rheumatology (EULAR) points to consider for use of antirheumatic drugs in reproduction, pregnancy, and lactation have been published. More information is available here. Photo by Anna Auza on Unsplash

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Latest publications from ENTIS members

Orna Diav-Citrin (Israeli TIS) and Corinna Weber-Schoendorfer (TIS Berlin) have published a mini narrative review of early pregnancy exposure to methotrexate and misoprostol (see here) Associate members Marleen van Gelder and Hedvig Nordeng (University of Oslo) have collaborated with researchers from the University of Queensland and the Norwegian Institute of Public Health to analyse data from linked Norwegian datasets to […]

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Study finds no increased risk of malformation following first trimester pseudoephedrine exposure

Researchers affiliated to the School of Public Health at Ben-Gurion University of the Negev (Beer-Sheva, Israel), have published the results of a study conducted using Clalit Health Services insurance claims data investigating malformation risks following maternal first trimester pseudoephedrine use. The results indicated that fetal exposure was not an independent risk factor for major congenital malformations, either overall or by […]

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New publications from ENTIS partners

Professor Lavinia Schuler-Faccini (Porto Alegre TIS) and colleagues have published an overview of epidemiological surveillance in congenital anomalies and rare diseases in Brazil. More information here. Dr Alice Panchaud (TIS Lausanne) and colleagues have published a retrospective analysis of Swiss claims data assessing exposure to potentially teratogenic medications before and during the first trimester of pregnancy. More information here. The […]

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