Intellectual difficulties in patients with fetal valproate syndrome

A collaborative of researchers from Manchester University, The University of Liverpool and Aston University have demonstrated that intellectual difficulties are a central feature of fetal valproate syndrome, and are more severe in their presentation in individuals with a diagnosis of valproate embryopathy. Full details of the study have been published in Neurotoxicology and Teratology.   Photo by Ben Mullins on Unsplash  

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Methods for assessing selection bias in pregnancy pharmacovigilance studies

Researchers from the University of Montreal have published a methodological paper describing analytical techniques which may be useful for assessing the extent and impact of selection bias which may arise as a consequence of delayed cohort inclusion. The study demonstrates three analytical approaches utilising a regional administrative dataset; full details are published in Pharmacology Research and Perspectives.   Photo by freestocks.org on Unsplash  

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Birth defect risks following maternal antihypertensive use

US National Birth Defects Study data has been analysed to investigate malformation risks following maternal antihypertensive medication use in pregnancy. Although the authors report some statistically significant associations with specific anomalies, these findings were not related to any particular class of medications. Furthermore, associations were seemingly based on small numbers of exposed and affected infants, and the impact of the […]

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