Study finds no increased risk of malformation following first trimester pseudoephedrine exposure

Researchers affiliated to the School of Public Health at Ben-Gurion University of the Negev (Beer-Sheva, Israel), have published the results of a study conducted using Clalit Health Services insurance claims data investigating malformation risks following maternal first trimester pseudoephedrine use. The results indicated that fetal exposure was not an independent risk factor for major congenital malformations, either overall or by […]

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New publications from ENTIS partners

Professor Lavinia Schuler-Faccini (Porto Alegre TIS) and colleagues have published an overview of epidemiological surveillance in congenital anomalies and rare diseases in Brazil. More information here. Dr Alice Panchaud (TIS Lausanne) and colleagues have published a retrospective analysis of Swiss claims data assessing exposure to potentially teratogenic medications before and during the first trimester of pregnancy. More information here. The […]

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Latest studies and publications

Several interesting studies have been published this week: Researchers affiliated with the School of Public Health at Ben-Gurion University of the Negev in Beer-Sheva, Israel have published an analysis of the Clalit Health Services insurance data investigating congenital malformation risks following first trimester papaverine use – see here. An analysis of the French National Health Data System provides data on […]

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Neurodevelopmental outcomes following prenatal exposure to systemic glucocorticoids

A collaboration of researchers from Aarhus University, University of Southern Denmark and the University of Copenhagen have published a nationwide population-based cohort study using Danish national registry datasets to investigate associations between prenatal exposure to systemic glucocorticoids and neurodevelopmental impairments. The study, which attempted to stratify glucocorticoid exposure due to prematurity (as a known risk factor for neurodevelopmental impairment), produced […]

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Data published by TIS Berlin: Trends in first trimester antiseizure medication use and treatment patterns

Researchers from the Embryotox Center of Clinical Teratology and Drug Safety in Pregnancy (TIS Berlin) at the Institute of Clinical Pharmacology and Toxicology (Charité – Universitätsmedizin) have published data from the German Embryotox cohort (2000 to 2018) analysing trends in antiseizure medication (ASM) use at conception and changes in first trimester treatment pattern among those with epilepsy as reported to […]

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Acetaminophen, ADHD and ASD; a Clinical Perspective jointly published by the ENTIS-OTIS Scientific Committees

Members of the ENTIS and OTIS Scientific Committees, with with contributions from Michael Ceulemans (KU Leuven, Belgium) PhD student Erika Gram (University of Southern Denmark, Denmark), have published a clinical perspective focussing on the the strengths and limitations of the published literature on the effect of maternal acetaminophen use in pregnancy on the child’s risk of developing attention-deficit and hyperactivity […]

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