Category: News

A collaboration between researchers from the PharmacoEpidemiology and Drug Safety Research Group at the University of Oslo and the Department of Epidemiology at the University of North Carolina Chapel Hill has provided a study emulating target trials using data from the Norwegian Mother, Father and Child Cohort Study. The trials investigate the effects of initiating benzodiazepine or z-hypnotic treatment in early, […]

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Researchers from TIS Zerifin in Israel have published a study investigating the effects of ADHD treatment with therapeutic amfetamines during breastfeeding and childhood development, measured using the Pediatric Quality of Life and Denver Developmental Scale assessment tools. The study findings described normal neurodevelopment with no significant adverse effects, suggesting therapeutic amphetamine use is likely compatible with breastfeeding. More information is […]

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A narrative review has been published appraising the safety evidence regarding the use of biological DMARDs in treating inflammatory arthritis in pregnancy. The authors conclude that during pregnancy, the benefits of disease control with biological DMARDs, when required in addition to conventional synthetic DMARDs, outweigh the risks. More information is available here. Photo by Anna Hecker on Unsplash

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Researchers from Aarhus University in Denmark have published a large population-based cohort study of paternal valproate use. The study found no increased risk of malformation diagnosis in the first year of life for the infants of men who used valproate immediately before or during the time of spermatogenesis (3 months prior to conception). Following the study population for a median […]

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Researchers from Ben-Gurion University of the Negev and Ariel University in Israel have published a population-based cohort study linking data from multiple Israeli healthcare databases. Exposure to either macrolide antibiotics as a group or specific macrolide antibiotics was not associated with miscarriage, and there was no evidence of a dose-response relationship between macrolide exposure and miscarriage. More information is available […]

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Combined guidance has been issued from the American Academy of Neurology, American Epilepsy Society, and the Society for Maternal-Fetal Medicine which provide recommendations around ASM use in pregnancy whilst considering the potential for adverse teratogenic, perinatal and neurodevelopmental outcomes. More information is available here.

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Researchers from the Karolinska Institutet in Stockholm, Sweden, have published a population-based cohort study examining the risks of autism, ADHD or intellectual disability following paracetamol (acetaminophen) use in pregnancy. No increased risks were identified in sibling control analyses, suggesting that associations observed in other models (i.e. non-sibling controlled) may have been attributable to confounding. More information is available here.

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Researchers from TEVA pharmaceuticals have published a small case series describing 232 prospective cases of paternal glatiramer acetate use, and the associated pregnancy and fetal outcomes, as extracted from the Teva Global Pharmacovigilance database. More information is available here. Photo by OPPO Find X5 Pro on Unsplash

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