Does extended follow-up period after birth improve precision of diagnosis of congenital anomalies?

The team at TIS Berlin (Pharmakovigilanz- und Beratungszentrum für Embryonaltoxikologie) have published the results of their long-term project investigating whether an extended follow-up period improves the detection of birth defects. The results of the study are published here, and an open access PDF was also kindly provided by the study authors. Photo by Christian Bowen on Unsplash

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ConcePTION project: Milk4baby decision trees published

A sub-study within the ConcePTION project led by researchers from the Swiss Teratology Information Service and the Department of Pharmaceutical and Pharmacological Sciences at KU Leuven in Belgium has resulted in the development of a clinical decision tree to guide researchers in selecting the most appropriate methodological approach for evaluating the safety of medication during breastfeeding. More details about the about […]

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Prospective case series of pregnancy outcomes following gestational CFTR modulator use published

A new collaboration between the Teratology Information Service CRAT (Centre de Reference sur les Agents Tératogènes) and the French Network of Pharmacovigilance Centres has produced the largest to date prospective case series of CFTR modulator exposed pregnancies. The article has been published in the Journal of Cystic Fibrosis, and more details are available here. Photo by Robina Weermeijer on Unsplash

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Latest publications from TIS Paris Cochin

Recent research conducted at TIS Paris Cochin includes: A comprehensive analysis into the safety of ifosfamide in pregnancy, including a review of literature cases, cases in the French pharmacovigilance database, and a disproportionality analysis of Vigibase. A comparative cohort study of pregnancy outcomes following CFTR modulator use in pregnancy. A nationwide cohort study investigating the impact of clomiphene citrate on […]

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Risk of autism spectrum disorder following maternal antiseizure medication use in pregnancy

A collaborative group of Brazilian researchers has published a systematic review and meta analysis of autism spectrum disorder risk following maternal antiseizure medication (ASM) use in pregnancy. The updated analysis provides pooled risk estimates for specific ASMs, demonstrating increased risks for carbamazepine, valproate and oxcarbazepine. More information can be found here.

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EULAR 2024 update published

An update to the existing European Alliance of Associations for Rheumatology (EULAR) points to consider for use of antirheumatic drugs in reproduction, pregnancy, and lactation have been published. More information is available here. Photo by Anna Auza on Unsplash

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