Tag: Featured

Utilising data from the Colorado-based Children’s Hospital Immunodeficiency Program (CHIP), a team of researchers have published a retrospective comparative cohort study of pregnancy and fetal outcomes following first trimester integrase inhibitor use (dolutegravir, elvitegravir or raltegravir). The study describes increased risks of congenital anomalies among the first trimester integrase inhibitor exposed in comparison with those born to women with HIV […]

Experts from 13 countries and professionally diverse backgrounds took part in the development of a series of recommendations focusing on the importance of including the study of infant neurodevelopment as a core feature of pregnancy drug safety studies. These recommendations outline the core neurodevelopmental outcomes, optimization of methodological approaches and barriers to conducting pregnancy drug safety studies including neurodevelopmental outcomes. […]

Researchers from Lyon, France have published an updated systematic review and meta-analysis of malformation risk following maternal first trimester proton pump inhibitor exposure. More information can be found here.

Researchers from Qilu Medical University, China, have published a comparative analysis of the safety of propylthiouracil and methimazole in the treatment of hyperthyroidism in pregnancy. More information can be found here. Photo by SHAMBHAVI SINGH on Unsplash

Researchers and ENTIS affiliates from KU Leuven, Belgium, have published details of their newly developed BELpREG data registration system which enables comprehensive “real-world” data collection on perinatal medication use and mother-infant outcomes via online questionnaires. More information about the development and design of the system available here.

Researchers from the UK Teratology Information Service have published an updated meta-analysis of studies investigating the risk of cardiac malformation following maternal first trimester methylphenidate use in pregnancy. The findings indicated a small statistically significant increased risk, but the authors advised caution in the interpretation of this finding given that the primary source studies are likely confounded. The brief report […]