Tag: Featured

A collaborative of Scandinavian researchers led from Aarhus University in Denmark have published a large prospective, population-based register study including over 4.5 million study subjects which investigated the risk of psychiatric disorders following in utero ASM exposure. The study findings indicate that n utero valproate, topiramate and levetiracetam exposure may be associated with increased risks of neurodevelopmental impairment, ADHD and/or […]

Researchers from Odense University Hospital in Denmark have published the results of a population-based observational comparative cohort study investigating pregnancy and infant outcomes following maternal corticosteroid use to treat inflammatory bowel disease (IBD). More information available here.

Researchers from Aarhus University in Denmark have published an updated analysis of linked data collected from Danish population-based healthcare registers, investigating major malformation risks among pregnancies exposed to antipsychotics in the first trimester in comparison with unexposed pregnancies. Robust sensitivity analyses were also conducted, including comparisons formed between exposed pregnancies, and pregnancies among women who only used antipsychotics prior to […]

Researchers affiliated to the University of Southern Denmark have published a systematic review examining pregnancy and childhood outcomes among mothers with multiple sclerosis. Data are also provided for DMT exposed pregnancies. More information are available here.

Researchers and ENTIS members from the Embryotox Center of Clinical Teratology and Drug Safety in Pregnancy, in Berlin, have published an observational study of newer anti-seizure medication use in pregnancy. The study has a focus on lacosamide, describing 55 prospective and 10 retrospective exposures. More information is available here, where the paper is openly available until 19th May 2023.

Researchers from the Innovative Medicines Initiative (IMI) ConcePTION project have published a set of recommendations about the core data elements which should be collected when performing studies of medication use in pregnancy. These recommendations include all the key variables that are required in studies assessing both immediate pregnancy/infant outcomes, and longer-term childhood outcomes following maternal medication use in pregnancy. Each […]

Researchers with access to the VigiBase database of adverse drug reactions have conducted a disproportionality analysis of adverse pregnancy outcomes to identify safety signals associated with ganciclovir or valganciclovir use in pregnancy. More information can be found here. The authors of the study have also provided ENTIS with a visual abstract of their study: Photo by Wengang Zhai on Unsplash

Researchers from the Sapienza University Working Group on Cystic Fibrosis in Pregnancy have published a case report on the outcome of pregnancy in a woman treated with elexacaftor, tezacaftor, ivacaftor combination during the second and third trimester of pregnancy (following discontinuation in the first trimester). More information available here. Photo by Mockup Graphics on Unsplash