Position statement: Live vaccine use following in utero or lactation infliximab exposure

In March 2022 the European Medicines Agency’s (EMA) published a direct healthcare professional communication (DHPC) regarding the use of live vaccines in infants exposed to infliximab in utero or during breastfeeding. The DHPC stated that live vaccines (e.g. BCG vaccine) should not be given to infants less than 12 months after birth following in utero infliximab exposure, and that administration […]

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Case report of bosentan and sildenafil use in lactation and medication disposition in breastmilk.

ENTIS affiliated researchers from the Department of Pharmaceutical and Pharmacological Sciences, KU Leuven have published a case report of bosentan and sildenafil use in lactation. This report, from the IMI ConcePTION project, presents the clinical and pharmacokinetic data of a single mother-infant pair exposed to bosentan and sildenafil for the treatment of pulmonary arterial hypertension (PAH) during lactation. More information […]

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No link between triptan use in pregnancy and ADHD in the offspring

ENTIS affiliated researchers from the Pharmacoepidemiology and Drug Safety Research Group, , PharmaTox Research Initiative at the University of Oslo have published a study investigating whether an association exists between maternal use of triptans during pregnancy and diagnosis or symptoms of attention-deficit hyperactivity disorder among their offspring. More information can be found here. Photo by Anthony Tran on Unsplash

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Topiramate use in pregnancy associated with increased risks of autism spectrum disorder and intellectual disability in the offspring

JAMA Neurology have recently published a population-based cohort study which used health and social register data from Denmark, Finland, Iceland, Norway, and Sweden to investigate neurodevelopmental outcomes of children (up to age 8) exposed to antiseizure medications in pregnancy. Increased risks of autism spectrum disorder and intellectual disability were observed for children exposed to topiramate in utero. More information can […]

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