Category: News

The Pan American Health Organizartion (PAHO) has issued an epidemiological alert describing possible cases of vertical Oropouche virus transmission (from mother to fetus) in Brazil. The alert describes two recent cases of suspected vertical transmission in pregnancy, one of which ended in intrauterine fetal death, the second in early pregnancy miscarriage. The alert also describes a small number of historical […]

Data collected from Dutch and Danish clinical records has been used to investigate the safety of allopurinol use in pregnancy. The authors also conducted a systematic review. More information is available here.

Pregnancy safety data for golimumab have been published using global pharmacovigilance data collected by Janssen Pharmaceuticals. The authors of the publication concluded that rates of adverse pregnancy outcomes and major congenital anomalies in prospectively reported pregnancy cases were consistent with published background rates for the general population. More information can be found here.

Researchers from the Pregnancy and Drug Information Center in Tokyo have published a comparative cohort study comparing fetal malformation outcomes between those exposed to (i) fluoroquinolones (fluoroquinolone group), (ii) β-lactams (infectious control group), or (iii) other agents considered to be nonteratogenic in humans (nonteratogenic control group) during the first trimester. The incidence of major congenital anomalies was not found to […]

A collaboration between researchers from the PharmacoEpidemiology and Drug Safety Research Group at the University of Oslo and the Department of Epidemiology at the University of North Carolina Chapel Hill has provided a study emulating target trials using data from the Norwegian Mother, Father and Child Cohort Study. The trials investigate the effects of initiating benzodiazepine or z-hypnotic treatment in early, […]

Researchers from TIS Zerifin in Israel have published a study investigating the effects of ADHD treatment with therapeutic amfetamines during breastfeeding and childhood development, measured using the Pediatric Quality of Life and Denver Developmental Scale assessment tools. The study findings described normal neurodevelopment with no significant adverse effects, suggesting therapeutic amphetamine use is likely compatible with breastfeeding. More information is […]

A narrative review has been published appraising the safety evidence regarding the use of biological DMARDs in treating inflammatory arthritis in pregnancy. The authors conclude that during pregnancy, the benefits of disease control with biological DMARDs, when required in addition to conventional synthetic DMARDs, outweigh the risks. More information is available here. Photo by Anna Hecker on Unsplash

Researchers from Aarhus University in Denmark have published a large population-based cohort study of paternal valproate use. The study found no increased risk of malformation diagnosis in the first year of life for the infants of men who used valproate immediately before or during the time of spermatogenesis (3 months prior to conception). Following the study population for a median […]

Researchers from Ben-Gurion University of the Negev and Ariel University in Israel have published a population-based cohort study linking data from multiple Israeli healthcare databases. Exposure to either macrolide antibiotics as a group or specific macrolide antibiotics was not associated with miscarriage, and there was no evidence of a dose-response relationship between macrolide exposure and miscarriage. More information is available […]