A small retrospective case series of pregnancies reported to an industry pharmacovigilance database has provided an additional 53 pregnancy outcomes following gestational adalimumab exposure. Findings from the study were published in Digestive Diseases. Photo by rawpixel on Unsplash
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A multi-centre observational study of vedolizumab use in pregnancy has been published in the Journal of Crohn’s and Colitis which provides a small amount of additional safety information. Photo by John Looy on Unsplash
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A collaborative of researchers from the University of York, AbbVie Biopharmaceuticals and the University of Pennsylvania have published an interesting feasibility study into the use of social media data for the purposes of pregnancy pharmacovigilance in Drug Safety. Photo by William Iven on Unsplash
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Researchers from the University of Montreal have published a methodological paper describing analytical techniques which may be useful for assessing the extent and impact of selection bias which may arise as a consequence of delayed cohort inclusion. The study demonstrates three analytical approaches utilising a regional administrative dataset; full details are published in Pharmacology Research and Perspectives. Photo by freestocks.org on Unsplash
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US National Birth Defects Study data has been analysed to investigate malformation risks following maternal antihypertensive medication use in pregnancy. Although the authors report some statistically significant associations with specific anomalies, these findings were not related to any particular class of medications. Furthermore, associations were seemingly based on small numbers of exposed and affected infants, and the impact of the […]
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A collaboration of researchers from the Netherlands Pharmacovigilance Centre (Lareb), Radboud University Medical Centre and the University of Groningen, have published details of their national pregnancy and medication exposure register pREGnant in Drug Safety. Photo by Ian on Unsplash
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Collaborators from the International Clearinghouse for Birth Defects Surveillance and Research have published an interesting commentary on the value of data sharing and networking between birth defects surveillance programs in the Journal of Community Genetics. Photo by Kelsey Knight on Unsplash
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Between the 4th and 8th September, UKTIS hosted the UK’s first Human Teratogens Education Course and the 3rd International Joint Meeting of the European Network of Teratology Information Services (ENTIS) and Organization of Teratology Information Specialists (OTIS) in Newcastle upon Tyne. Delegates attended from around the globe and were treated to presentations from some of the most influential researchers and […]
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In January 2017 Obstetrics & Gynecology published an article on Angiotensin-Converting Enzyme Inhibitors and the Risk of Congenital Malformations“ by Brian T Bateman et al. As data on the teratogenic potential of ACE inhibitor (ACEI) are partly conflicting, this pharmacoepidemiologic study wanted to analyze the association between first trimester ACEI exposure and the risk of overall major malformations, of cardiovascular […]
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A collaborative ENTIS study recently published in Reproductive Toxicology (Volume 67, Pages 26-34) has provided no signal that varenicline is a major human teratogen. This collaborative ENTIS study was undertaken by researchers based at teratology information services in the United Kingdom, Israel, France (Paris), Germany (Berlin), Australia, the Netherlands, Finland and Turkey (Izmir), who collectively joined data from over 400 […]
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